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ACAPS inhibit the formation of PDGF-induced dorsal actin–rich ruffles in NIH 3T3 fibroblasts. The fraction of cells forming dorsal ruffles in response to PDGF was determined in cells transfected with either empty vector or vectors directing expression of the indicated ACAPs, including point mutants, [R448Q]ACAP1 and[R442Q]ACAP2, that lack GAP activity. The data presented are the mean ± SEM of five experiments.
