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. 2000 Oct 30;151(3):709–718. doi: 10.1083/jcb.151.3.709

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© 2000 The Rockefeller University Press

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graphic file with name JCB0005112.f6a.jpg — Primary cilia in the kidney of Tg737 mutant mice are shorter than normal. (a) Kidneys from 4-d-old pups were fixed with glutaraldehyde, freeze fractured, metal impregnated, and examined by scanning electron microscopy. Numerous cilia were found on the epithelial cells in the tubules and collecting ducts of the wild-type mice (+/+). Cilia were also found in the homozygous mutant (−/−) pups, but they were usually <2-μm long and most were only short stubs. (b) Cilia length in kidneys of 4-d-old mice. Cilia were measured in scanning electron micrographs of tubules located distal to the proximal tubule. Wild-type cilia averaged 3.1 ± 1.4 μm (n = 50), whereas the mutant cilia averaged 1.0 ± 0.6 μm (n = 50). (c) Cilia length in kidneys of 7-d-old mice. The cilia lengths were measured in scanning electron micrographs of tubules located distal to the proximal tubule. Wild-type cilia averaged 3.5 ± 1.7 μm (n = 50), whereas the mutant cilia averaged 1.3 ± 0.6 μm (n = 50).

graphic file with name JCB0005112.f6bc.jpg — Primary cilia in the kidney of Tg737 mutant mice are shorter than normal. (a) Kidneys from 4-d-old pups were fixed with glutaraldehyde, freeze fractured, metal impregnated, and examined by scanning electron microscopy. Numerous cilia were found on the epithelial cells in the tubules and collecting ducts of the wild-type mice (+/+). Cilia were also found in the homozygous mutant (−/−) pups, but they were usually <2-μm long and most were only short stubs. (b) Cilia length in kidneys of 4-d-old mice. Cilia were measured in scanning electron micrographs of tubules located distal to the proximal tubule. Wild-type cilia averaged 3.1 ± 1.4 μm (n = 50), whereas the mutant cilia averaged 1.0 ± 0.6 μm (n = 50). (c) Cilia length in kidneys of 7-d-old mice. The cilia lengths were measured in scanning electron micrographs of tubules located distal to the proximal tubule. Wild-type cilia averaged 3.5 ± 1.7 μm (n = 50), whereas the mutant cilia averaged 1.3 ± 0.6 μm (n = 50).