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Schematic of the MLCK isoforms and MLCK truncations. The long MLCK is identical to the short MLCK, with the exception of a novel NH2-terminal extension of 934 residues. The hatched boxes represent the six IgG-C2 motifs present in the NH2-terminal extension, and the three IgG-C2 motifs present in the short MLCK. The black boxes represent the DXRXXL motifs that span the NH2-terminal extension/short MLCK junction.
