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EGFR specifically regulates Rab5a function. (A) Cells expressing EGFR:WT were transfected with virus alone or virus encoding Rab5a, Rab5b, or Rab5c, and the internalization of HRP in the presence or absence of 100 nM EGF was carried out for 10 min at 37°C (mean ± SD, n = 3). (B) Cells expressing EGFR:WT were transfected as in A. After transfection, the uptake of 125I-EGF was carried out at 37°C for 10 min as described in Materials and Methods. Mean ± SD, n = 3.
