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. Author manuscript; available in PMC: 2008 Nov 1.
Published in final edited form as: J Pain. 2007 Jul 23;8(11):850–860. doi: 10.1016/j.jpain.2007.05.015

Table 1.

Structures and CB1 activity of selected congeners of rimonabant.

graphic file with name nihms-34707-t0008.jpg

Drug CB1 Ki (nM) R1 R2 R3 R4
Rimonabant 6.2 2,4-dichloro 4-chloro methyl graphic file with name nihms-34707-t0009.jpg
O-1691 1.5 2,4-dichloro 4-(n-pentyl) bromo graphic file with name nihms-34707-t0010.jpg
O-1876 657 2,4-dichloro 4-chloro methyl graphic file with name nihms-34707-t0011.jpg
O-848 2450 2,4-dichloro 4-chloro methyl graphic file with name nihms-34707-t0012.jpg

Literature Ki values are shown34 for drugs synthesized and tested presently.