Figure 5. AMPK activates FOXO/DAF-16 dependent transcription of sod-3.
(A) sod-3 mRNA is increased in CA AMPK γ2 transgenic worms (CA3) compared with empty vector control transgenic line (EV1) and this increase is daf-16 dependent. The results presented correspond to the mean and SEM of three independent quantitative RT-PCR experiments. *: p<0.05; **: p<0.01; ***: p<0.001 in a one-way ANOVA statistical test. (B) sod-3 was decreased in aak-2 mutant worms compared with N2 wild type worms. The results presented correspond to the mean and SEM of two independent experiments: *: p<0.05 in a paired t-test.