Figure 3.

Changes in T_c and I_Cl,swell during a prolonged reduction of OSM_o. (A) Changes in T_c (solid line) and I_Cl,swell (circles) as OSM_o was lowered from 320 to 240 mOsm. (B) Average current density (circles) and relative volume V/V₀ (solid line) during a 450-s reduction of OSM₀ from 320 to 240 mOsm (n = 10). The broken line in A and B represents the best fit of the model. In this panel, time 0 corresponds to the time at which OSM_o was reduced. (C) Model prediction of V/V₀ (solid lines) and Γ_i (broken lines) for dialyzed (d) and nondialyzed (nd) cells.