The mean rCBF for the 10 subjects at the location of the four strongest activations identified in the subtraction analysis involving the high state of thirst (100% infusion, maximum thirst, and wet mouth) compared with the six scans in which thirst was absent or minimal. The maximal rCBF was reached with the wet mouth scan, and a clear decrease of rCBF occurred 3 min after drinking water to satiation, and by 45 and 60 min, it had returned to the initial rCBF level.