Figure 3.

Summary of amiloride-sensitive whole-cell conductances measured in oocytes coexpressing α-, β-, and γ-ENaC and different ABC transporters. In oocytes expressing only ENaC (ENaC + water) or coexpressing ENaC with either MDR1, SUR1, or YCF1, no changes of the amiloride-sensitive ENaC conductance were observed on stimulation with IBMX and forskolin, whereas activation of CFTR significantly inhibited ENaC conductance. The numbers of experiments are shown in parentheses. ∗, Significant difference from control (P < 0.0001).