Figure 4.

Average contact maps (above the diagonals) compared with the native contact maps (below the diagonals) for (a) the denatured state and (b) the transition structures. Colors indicate frequency of contacts. The average contact map for the denatured state was calculated from the entire isothermal trajectory at T = 2.1. The average contact map for the transition structures is the contact map from isothermal simulation at the T_t for the structures with the transient energy and cRMSD values (the same defined in the Fig. 3 caption). The most persistent contacts between the nucleus residues are circled.