Table 2.

Comparison of Least Squares (Predicted) Means by Category, Controlled for Covariates (age, sex and parasitemia) For Biomarkers Showing Overall Statistically Significant Differences between the three Study Groups

BIOMARKER	OVERALL P VALUE	P VALUE FOR PAIRED GROUPS
		CM vs. NM	CM vs. SMA	SMA vs. NM
Serum IP-10	0.005	0.002	0.001	NSS
CSF IP-10	0.005	0.001	0.004	NSS
CSF IL-8	0.0005	0.0001	0.001	NSS
CSF MIP-1β	0.0005	0.0001	0.001	NSS
CSF PDGFbb	0.008	0.0002	0.01	NSS
CSF IL-1ra	0.002	0.0004	0.005	NSS
CSF Fas-L	0.04	0.002	NSS	NSS
CSF sTNF-R1	0.0001	0.00001	0.0002	NSS
CSF sTNF-R2	0.001	0.0001	0.002	NSS

Statistically significant differences in biomarkers between the three disease groups determined by multivariate analyses [Comparison of Least Squares (Predicted) with Bonferonni correction] after modeling and controlling for covariates (age, sex, and parasitemia); P < 0.05 considered statistically significant; NSS, not statistically significant.