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A unified scheme for enediyne core biosynthesis implicating the enediyne PKS (PKSE) as responsible for a common polyketide intermediate and enediyne PKS accessory enzymes, in conjunction with the PKSE, to diverge into the 9- or 10-membered enediyne core pathways. Atoms that were incorporated intact from the acyl CoA precursors to the enediyne cores 1, 7, and 8 (15–17) are shown in bold red.
