Fig. 1.

SREBP-2 mediated activation of the entire pathway for cholesterol synthesis in mammalian cells. Key biosynthetic intermediates are highlighted in yellow. Red italics denotes the fold increase in mRNA levels for each enzyme in TgSREBP-2 liver. Each value is the average of the two microarray hybridizations listed in Tables 1 and 3. *, Desmosterol reductase was not represented on the microarray. The fold-increase value is from real-time PCR. †,17β-Hydroxysteroid dehydrogenase-7 has not been confirmed as a cholesterol biosynthetic enzyme.