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Model showing the pathway-independent formation of m7GMP. After deadenylation, a mRNA can be degraded 3′–5′ by the exosome generating free m7GpppN. Alternatively, the mRNA can undergo decapping by hDcp2, generating m7GDP and a 5′-phosphorylated mRNA. RNAs degraded by the NSD and NMD pathways also generate m7GpppN and m7GDP, respectively. Both products are converted to m7GMP by DcpS. Thus, mRNA decay leads to the formation of m7GMP, irrespective of the pathway followed.
