Fig. 4.

Repeated separation is critical for GABAR functional changes. (a) The long-term changes in GABAR zinc sensitivity observed in the HMS-30/360 group were similar to those observed after repeated brief separations (HMS-30/30) but not a single long separation (HMS-360). (b) The potentiation of zolpidem on GABA currents was also similar between both repeated separation groups (HMS-30/360 and HMS-30/30) and different from the nonhandled groups (*, P < 0.05; **, P < 0.01; one-way ANOVA and Tukey's test for post hoc comparison).