Table 1. Genes bound by p65 and regulated in response to TNF-α stimulation.
| Gene symbol | Description | p65-binding site (relative to ATG) |
|---|---|---|
| Up-regulated | ||
| ZBED4* | Zinc finger, BED domain 4 | +6.4 kb†, +28.6 kb†, +32.5 kb |
| ZNF378 | Zinc finger, DHHC domain 1 | +3.6 kb† |
| PIK4CA* | Type II phosphatidylinositol 4-kinase | -4.5 kb, -325 bp, and 8 internal |
| AP000557.3 | Similar to human PIK4CA | +543 bp, +5.4 kb |
| EWSR1* | Ewing sarcoma breakpoint region 1 | +1740 bp |
| SMC1L2 | Mitosis-specific chromosome segregation (SMC1)-like 2 | -5 kb, +30 kb |
| NF2* | Neurofibromatosis 2 | +61 kb |
| ARFGAP3* | ADP-ribosylation factor GTPase activating protein 3 | -10 kb |
| KIAA0542 | mRNA for KIAA0542 | +25, +32, +41 kb |
| AC007050.4* | POM121-like 1 | +697 bp |
| AC005005.6 | Homo sapiens cDNA: FLJ23382 | +32 kb |
| Down-regulated | ||
| BSAC/MKL1* | Megakaryoblastic leukemia 1 | -3 kb, -100 bp, +30 kb† MKL1* |
| SBF1* | SET binding factor 1 | +5.5 kb† |
| dJ756G23.3* | Similar to Drosophila Tr:Q24191 transcriptional repressor | +10 kb† |
| RABL2B | RAB—RAS family-like 2B | +15 kb |
| ADTB1 | Adaptin beta 1 (beta prime) | +4.8 kb† |
| bA247113.2 | Matches EST sequences | -18.5 kb, -4 kb |
*
p65 binding confirmed by PCR.
†
First intron of gene.