Table 1. General CpG island attributes.
Methylation-prone (n = 15)
|
Methylation-resistant (n = 47)
|
||||
---|---|---|---|---|---|
Attribute | Mean ± SD* | Range | Mean ± SD* | Range | P value* |
Length, bp | 1,098.4 ± 586.0 | 473-2718 | 1,098.4 ± 630.7 | 228-3182 | 1.00 |
%C+G | 69.6 ± 4.31 | 61.7-75.8 | 68.8 ± 4.99 | 57.7-78.9 | 0.57 |
CGo/CGe | 0.87 ± 0.08 | 0.77-1.01 | 0.85 ± 0.08 | 0.66-1.01 | 0.29 |
Sp1 sites† | 0.47 ± 0.64 | 0-2 | 0.70 ± 0.91 | 0-3 | 0.36 |
Sequences were analyzed by using the NEWCPGREPORT algorithm (http://www.uk.embnet.org/Software/EMBOSS) by using a sliding window of 200 bp and a step increment of 1.
Groups were compared by Student's t test.
Number of occurrences per sequence based on the consensus GRGGCRGGGW.