Table 2. Gene expression in WS and normal old cells relative to normal young cells.
| GenBank | Old* | WS* | Gene name | Synonym |
|---|---|---|---|---|
| DNA/RNA metabolism and chromosomal processing | ||||
| AA459922 | 1.7 | 1.7 | Methyl-CpG binding domain protein 1 | MBD1 |
| AA450265 | 1.6 | 1.3 | Proliferating cell nuclear antigen | PCNA |
| AA029451 | 1.4 | 1.5 | Transcription factor 7-like 2 (T-cell specific, HMG-box) | TCF7L2 |
| AA485944 | -1.5 | -1.5 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72 kDa) | DDX17 |
| AA406285 | -1.8 | -2.0 | DR1-associated protein 1 (negative cofactor 2 alpha) | DRAP1 |
| AA136566 | -1.4 | -1.6 | Forkhead box M1 | FOXM1 |
| AA253413 | -1.4 | -1.6 | Friedreich ataxia | FRDA |
| AA608514 | -1.5 | -1.5 | H3 histone, family 3B (H3.3B) | H3F3B |
| AA291389 | -1.2 | -1.5 | Interferon-stimulated transcription factor 3, gamma (48 kDa) | ISGF3G |
| AA282537 | -1.6 | -1.7 | MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) | MEF2B |
| AA479052 | -2.0 | -2.1 | Polymerase (RNA) II (DNA directed) polypeptide A (220 kDa) | POLR2A |
| AA460830 | -1.4 | -1.6 | Polymerase (RNA) II (DNA directed) polypeptide J (13.3 kDa) | POLR2J |
| AA496809 | -1.5 | -1.8 | SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin | SMARCA1 |
| AA446018 | -1.4 | -1.5 | SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin | SMARCB1 |
| R91259 | -1.7 | -1.4 | Transcription factor BMAL2 | LOC56938 |
| AA465369 | -1.8 | -2.0 | Transcription factor Dp-2 (E2F dimerization partner 2) | TFDP2 |
| AA232647 | -1.9 | -1.6 | Zinc finger protein 161 | ZNF161 |
| AA252169 | -1.5 | -1.7 | Zinc finger protein 193 | ZNF193 |
| Cell growth | ||||
| AA262988 | -1.4 | -1.6 | Brain-derived neurotrophic factor | BDNF |
| AA480880 | -1.6 | -1.7 | Butyrate response factor 2 (EGF response factor 2) | BRF2 |
| AA458507 | -1.6 | -1.6 | Colony-stimulating factor 3 receptor (granulocyte) | CSF3R |
| AA443093 | -1.3 | -1.6 | Fbroblast growth factor receptor 2 | FGFR2 |
| AA001614 | -1.6 | -1.5 | Insulin receptor | INSR |
| N54596 | -1.7 | -1.7 | Insulin-like growth factor 2 (somatomedin A) | IGF2 |
| T62547 | -1.6 | -1.5 | Insulin-like growth factor 2 receptor | IGF2R |
| AA487034 | -1.5 | -1.5 | Transforming growth factor, beta receptor II (70-80 kDa) | TGFBR2 |
| Mitochondrial function | ||||
| W44701 | -1.7 | -1.8 | Solute carrier family 25 (mitochondrial carrier) | SLC25A6 |
| AA411554 | -1.8 | -1.8 | Solute carrier family 25 (mitochondrial carrier) | SLC25A16 |
| Cancer-related | ||||
| AA486403 | 1.7 | 2.1 | N-myc downstream-regulated | NDRG1 |
| AA447730 | 1.6 | 1.3 | Plm-1 oncogene | PIM1 |
| W72473 | 1.5 | 1.1 | Phosphoinositide 3-kinase, catalytic, alpha polypeptide | PIK3CA |
| H09066 | -1.6 | -1.7 | BRCA1-associated protein 1 (ubiquitin carboxy-terminal hydrolase) | BAP1 |
| AA425947 | -1.5 | -1.8 | Dickkopf (Xenopus laevis) homolog 3 | DKK3 |
| AA489246 | -1.9 | -2.0 | Suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) | ST14 |
| AA261635 | -1.6 | -1.5 | Suppression of tumorigenicity 16 | ST16 |
| Stress response, DNA repair, and cell death/apoptosis | ||||
| AA598874 | 1.4 | 1.7 | Antioxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium-independent phospholipase A2) | KIAA0106 |
| H11660 | 1.8 | 1.9 | p53-induced protein | PIG11 |
| AA453410 | 1.4 | 1.6 | Tumor necrosis factor receptor superfamily, member 10b | TNFRSF10B |
| AA459263 | -1.9 | -1.8 | BCL2-related protein A1 | BCL2A1 |
| AA427906 | -1.5 | -1.5 | Beclin 1 (coiled-coil, myosin-like BCL2-interacting protein) | BECN1 |
| AA455281 | -1.5 | -1.6 | Defender against cell death 1 | DAD1 |
| AA281945 | -1.7 | -1.5 | Mitogen-activated protein kinase-activating death domain | MADD |
| AA293365 | -1.3 | -1.5 | Mitogen-activated protein kinase kinase 4 | MAP2K4 |
| R85257 | -1.8 | -1.9 | Protein tyrosine kinase 2 beta | PTK2B |
| AA496782 | -1.5 | -1.5 | Requiem, apoptosis response zinc finger gene | REQ |
| AA446223 | -1.9 | -1.7 | TGFB1-induced antiapoptotic factor 1 | TIAF1 |
| Cell cycle | ||||
| AA598974 | 1.7 | 1.6 | Cell division cycle 2, G1 to S and G2 to M | CDC2 |
| AA598776 | -1.8 | -1.7 | CDC20 (cell division cycle 20, S. cerevisiae, homolog) | CDC20 |
| T81764 | -1.5 | -1.6 | Cell division cycle 27 | CDC27 |
| Signal transduction | ||||
| AA432271 | 1.9 | 2.1 | Protein kinase, AMP-activated, beta 1 noncatalytic subunit | PRKAB1 |
| N78582 | 1.6 | 1.8 | Protein kinase, AMP-activated, beta 2 noncatalytic subunit | PRKAB2 |
| AA485366 | 1.2 | 1.5 | Protein kinase, cAMP-dependent, regulatory, type I, beta | PRKAR1B |
| AA125779 | -1.5 | -1.5 | Adenylate cyclase 7 | ADCY7 |
| H29256 | -1.6 | -1.6 | Calcium channel, voltage-dependent, L type, alpha 1D subunit | CACNA1D |
| AA456830 | -1.9 | -1.9 | Diacylglycerol kinase, alpha (80 kDa) | DGKA |
| AA450003 | -1.9 | -1.7 | Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 4 | DYRK4 |
| AA521346 | -1.7 | -1.6 | Serine threonine protein kinase | NDR |
| Immune-related | ||||
| AA411324 | -1.4 | -1.6 | Interleukin 13 receptor, alpha 1 | IL13RA1 |
| AA057204 | -1.5 | -1.4 | Interleukin 2 receptor, beta | IL2RB |
| Protein metabolism | ||||
| AA450227 | -1.6 | -1.5 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | PSMD4 |
| AA598815 | -1.5 | -1.5 | Proteasome (prosome, macropain) subunit, alpha type, 5 | PSMA5 |
| T57841 | -1.6 | -1.7 | Ubiquitin fusion degradation 1-like | UFD1L |
| AA490124 | -1.8 | -1.7 | Ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) | UBE2N |
| AA488626 | -1.8 | -1.9 | Ubiquitin-like 1 (sentrin) | UBL1 |
Shown is a representative selection of the 435 genes differentially expressed when either WS or normal old cells were compared with normal young cells, including the 249 to which function was annotated.
*
Fold difference in gene expression relative to normal young.