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. 2003 Oct 3;100(21):12325–12330. doi: 10.1073/pnas.2033229100

Fig. 2.

Fig. 2.

Appearance of neurological abnormalities and decreased survival in PPT2 knockout mice. (A) Kaplan–Meier analysis of clasping phenotype in the tail suspension test in WT and PPT2 knockout mice (n = 58 and 319, respectively). (B) Kaplan–Meier survival curve for WT and PPT2 knockout mice (n = 120 and 53, respectively). Curves shown are significantly different from each other at a level of P < 0.001 (two-tailed Mantel–Haenszel log rank test). Median time to appearance of clasping phenotype was 152 and 266 days, and median survivals were 216 days and 334 days, for PPT1 and PPT2 knockout mice, respectively. Dotted lines indicate similar data for PPT1 knockout mice shown for comparison (n = 99, data for PPT1 knockout mice updated from ref. 10).