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. 2003 Oct 6;100(21):12438–12443. doi: 10.1073/pnas.2132992100

Fig. 5.

Fig. 5.

Inhibition of dopamine synthesis prevents CDCrel-1-induced neurodegeneration. Rats were treated with the TH inhibitor AMPT or saline (as a control) beginning 9 days after rAAV-CDCrel-1 injection. To confirm the potency of AMPT, dopamine levels were compared by HPLC in the uninjected hemispheres of saline- and AMPT-treated rats at 12 days after rAAV injection (n = 4 rats per group) (A). Shown are TH-positive neurons (B) and percentage of TH fiber density (C) at day 15 in rAAV-CDCrel-1-injected and -uninjected brain hemispheres of saline- and AMPT-treated rats (neuron counts: n = 4 rats per group, four to six sections per rat; TH fiber density: n = 4 rats per group, four sections per rat). (D) Expression of CDCrel-1 in nigral dopamine neurons of AMPT-treated rats at day 15. Data were evaluated statistically by ANOVA and Fisher's probable least-squares difference test (***, P < 0.001; **, P < 0.01; *, P < 0.05, compared to the uninjected hemisphere).