Skip to main content
. 2003 Oct 1;100(21):12468–12473. doi: 10.1073/pnas.1633692100

Fig. 5.

Fig. 5.

Reelin and TAG-1 are both required for the tangential migration of MGE-derived neurons. (A) Diagram of a forebrain slice illustrating the injection point (gray) of CMTMR or DiI in the MGE. (B) Migrating neurons invade the cortex in a control slice; CMTMR. (C) A cultured slice, labeled with DiI and incubated with the blocking antibody CR-50, showed arrest of the migration at the basal ganglia. (D–F) CMTMR. (D) Incubation with the blocking antibody 4D7/TAG-1 showed a milder arrest of the migration, as compared with C. Incubation with the monoclonal antibody 142 to reelin (E) or the monoclonal antibody 12E3 to PSA-NCAM (F) did not impair the migration. (Scale bars: B, 100 μm; C and D, 200 μm; and E and F, 50 μm.)