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(A) BDNF expression in visual cortex is down-regulated in wild-type but not in BDNF transgenic mice during DR. Coronal brain sections from 5-week-old wild-type (WT) and BDNF transgenic mice under light-rearing (LR) or DR conditions were hybridized with a BDNF oligonucleotide probe that detects both the endogenous and transgenic BDNF mRNA. (Bottom) Higher magnifications of DR cases. (B) Postnatal expression of BDNF in visual cortex of wild-type and BDNF transgenic mice.
