Table 1.

Characteristics of wild-type and mutant PTH receptors

Receptor	125I-PTH binding		Inositol phosphate production
	KD, nM	Bmax, pmol/mg protein	EC50, nM	Max. stimulation, fold
PTHR	29  ±  3.1	35.5  ±  0.5	34.3  ±  6.4	4.9  ±  1.0
T480	14  ±  1.2	28.0  ±  1.2	12.0  ±  1.3	7.0  ±  1.4
PTHR-HA	28  ±  3.4	18.1  ±  0.2	29.6  ±  3.0	2.3  ±  0.3

Experiments were done in transiently transfected COS-1 cells overexpressing the indicated receptor. Values are mean ± SE (n = 3–9).