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Sequence of the proline-rich SH3-binding motifs in NS5A. Amino acid (a.a.) sequence alignment of NS5A from various HCV species revealed conservation (residues enclosed in boxes) of both class I and II proline-rich motifs (26). P denotes the highly conserved proline residue. + tends to be basic residue; Φ, hydrophobic residue; X, any residue.
