Table 1.
Mammary Morphology at End Stage
| Treatment | Mammary abnormalities
|
|
|---|---|---|
| Castrated | Sham surgery | |
| PRL × TGF-α | Macrocysts (10 of 12) | Macrocysts (9 of 9) |
| Complex/papillary (4 of 10) | Complex/papillary (6 of 9) | |
| Simple/papillary (6 of 10) | Simple/papillary (3 of 9) | |
| EH* (9 of 12) | EH* (7 of 9) | |
| Dilated ducts (8 of 12) | Dilated ducts (7 of 9) | |
| Adenosis (9 of 12) | Adenosis (3 of 9) | |
| MINs† (3 of 12) | MINs† (3 of 9) | |
| Squamous neoplasia (2 of 12) | ||
| TGF-α | No lesions present (8 of 8) | No lesions present (8 of 8) |
| PRL | No lesions present (9 of 9) | No lesions present (7 of 7) |
| Nontransgenic FVB/N | No lesions present (8 of 8) | No lesions present (8 of 8) |
End stage is defined as tumor size reaching 1.5 cm diameter or 1 year of age.
*
Epithelial hyperplasia.
†
Mammary intraepithelial neoplasias.