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In vitro transactivation activity profile of rosiglitazone and muraglitazar
| Compound |
Transactivation Ec50 (μM) |
||
|---|---|---|---|
| hPPARγ | hPPARα | hPPARδ | |
| Rosiglitazone (BRL 49653) | 0.056±0.017 | >30 | >30 |
| Muraglitazar (BMS 298585) | 0.16±0.04 | 0.28±0.03 | >30 |
EC50 values for PPARα, γ or δ agonist activity were calculated as the concentration of the test ligand (μM) required for the half-maximal fold induction of luciferase activity. Data shown are means±s.e.m. from three experiments for each treatment.
