Figure 2.

Effects of local injection of taltirelin. I.c.v. (a) but not i.t. (b) administration of taltirelin hydrate (tal, 0.1 and 0.3 μg) generated antinociceptive effects in the tail flick (left) and tail pressure (right) tests, indicating that taltirelin has supraspinal sites of action. Taltirelin was injected at time zero. Each point represents the mean (±s.e.m.) result from six mice. Ordinates: mean normalized tail flick latencies (tail flick test; left) and nociceptive thresholds (tail pressure test; right). Abscissae: time in minutes after taltirelin application. The asterisks indicate data points for which a significant difference between the control and taltirelin-treated groups was observed, as determined by two-tailed non-parametric Bonferroni-type multiple comparisons following the Kruskal–Wallis test (two comparisons in three groups, ^*P<0.05).