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. 2007 Jan 2;150(4):509–518. doi: 10.1038/sj.bjp.0707002

Figure 7.

Figure 7

Inhibition of the protein phosphatase activity by immunosuppressants. Mononuclear cell extracts were prepared and dephosphorylation of the RII phosphopeptide was followed in the absence or presence of either FK506 (10 nM), cysclosporine, (CsA, 1 μM) or EGTA (5 mM). EGTA and cyclosporine, but not FK506, inhibited the protein phosphatase activity to a statistically significant (*P<0.05) degree. Results are expressed as the percent inhibition of phosphatase activity. Results are means and vertical lines, s.e.m., n=5.