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Arthritis score (a) and paw oedema (b) in lean and obese rats injected with CFA in the right hind paw. Rats received CFA or saline on day 0. The severity of arthritis was rated using an arbitrary score, as described in the Methods. The oedema volume was measured with a plethysmometer. Data are mean±s.e.m. (vertical lines) from 6 to 12 rats. *P<0.05, **P<0.001 vs CFA lean rats (two-way ANOVA plus Newman–Keuls test).
