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Effect of a 7-day treatment with R on arthritis score in lean (a) and obese (b) rats injected with CFA in the right hind paw. The severity of arthritis was rated using an arbitrary score, as described in the Methods. Rats received CFA or saline on day 0 and were given rimonabant daily from day 7 to day 14. Data are mean±s.e.m. (vertical lines) from 5–12 rats. *P<0.05 vs CFA only (two-way ANOVA plus Newman–Keuls test).
