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Effect of a 7-day treatment with rimonabant (R) on thermal hyperalgesia in lean (a) and obese (b) rats injected with CFA in the right hind paw. Thermal hyperalgesia was tested by the plantar test as described in the Methods. Results are expressed as response latency in seconds. Rats were given rimonabant daily from day 7 to 14. Data are means±s.e.m. (vertical lines) from 5 to 12 rats. **P<0.001 vs CFA only; °P<0.05, °°P<0.001 vs controls (two-way ANOVA plus Newman–Keuls test).
