Figure 6.

Effect of a 7-day treatment with rimonabant (R) on mechanical allodynia in lean (a) and obese (b) rats injected with CFA in the right hind paw. Mechanical allodynia was tested by the von Frey test as described in the Methods. Results are expressed as the mechanical response threshold in grams. Rats were given rimonabant daily from day 7 to 14. Data are means±s.e.m. (vertical lines) from 5 to 12 rats. ^*P<0.05, ^**P<0.001 vs CFA only; °P<0.05, °°P<0.001 vs controls; ^ΔP<0.05, ^ΔΔP<0.001 vs rimonabant treated lean rats (two-way ANOVA plus Newman–Keuls test).