Table 1.
Baseline mean arterial pressure, heart rate, core body temperature and locomotor activity in rats prior to treatment with vehicle, amphetamine derivatives or BRL 44408 (BRL)
| Vehicle | MDMA | MDEA | MDA | BRL vehicle | BRL MDMA | |
|---|---|---|---|---|---|---|
| Mean arterial pressure (mmHg) | 105±3 | 103±2 | 99±3 | 98±1 | 107±3 | 108±2 |
| Heart rate (min−1) | 392±12 | 358±19 | 379±11 | 355±12 | 348±9 | 349±7 |
| Body temperature (°C) | 38.3±0.1 | 38.1±0.1 | 37.9±0.1* | 37.8±0.1* | 37.8±0.1 | 37.8±0.1 |
| Locomotor activity (counts min−1) | 5.4±2.4 | 1.1±0.5 | 1.2±0.5 | 1.0±0.4 | 2.7±1.6 | 6.0±3.1 |
Values are the means±s.e.m. (n=6–9).
*
Denotes significantly different from vehicle, P<0.05.