Table 4.
Affinity of MDMA, MDEA and MDA for α1A-adrenoceptor ligand-binding sites in rat vas deferens, α2A-adrenoceptor ligand-binding sites in rat submandibular gland, α2B-adrenoceptor ligand-binding sites in rat kidney and α2C-adrenoceptor ligand-binding sites expressed in sf9 cell membranes
| Drug pKi (−log M) | 1A | 2A | 2B | 2C |
|---|---|---|---|---|
| MDMAa | 4.34±0.32 | 5.31±0.14 | 5.14±0.16 | 5.11±0.05 |
| MDEA | 5.39±0.04* | 4.69±0.15* | 4.88±0.31 | 4.81±0.12 |
| MDA | 4.95±0.19 | 4.97±0.14 | 5.06±0.07 | 4.69±0.07 |
Values are the mean pKi (−log M)±s.e.m. (n=4).
P<0.05 denotes significantly different from MDMA.
MDMA data taken from Lavelle et al. (1999).