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. 2007 Jun 25;151(8):1343–1351. doi: 10.1038/sj.bjp.0707352

Figure 1.

Figure 1

Interaction of PPARγ ligands with FAAH in rat brain membrane fractions. (a) thiazolidinediones; (b) other PPARγ activators; (c) PPARγ antagonists. The compounds were preincubated with the homogenates for 10 min before addition of 2 μM [3H-Et]AEA and incubation for a further 10 min (assay pH 7.4). Data are means±s.e.m. (when not enclosed by the symbols), n=3. AEA, anandamide (arachidonoylethanolamide); FAAH, fatty acid amide hydrolase; MCC-555, [[6-[(2-fluorophenyl)methoxy]-2-napthalenyl]methyl]-2,4-thiazolidinediones; PPAR, peroxisome proliferator-activated receptor; T0070907, 2-chloro-5-nitro-N-4-pyridinyl-benzamide.