Figure 4.

Effect of ciglitazone upon the hydrolysis of [³H]AEA. The plates were preincubated with ciglitazone (a for C6 cells, c for RBL2H3 cells) or rosiglitazone (b, C6 cells) for 10 min followed by addition of [Et-³H]AEA (0.1 (a and b) or 0.2 μM (c)) and 20 min incubation. Values shown are means±s.e.m., n=3–6. ^*P<0.05 vs the respective control value, Dunnett's multiple comparison test following significant one-way ANOVA for repeated measures for the compound. AEA, anandamide (arachidonoylethanolamide); ANOVA, analysis of variance.