Figure 4.
Effects of cannabidiol (CBD) (intraperitoneal (i.p.) treatment for 7 consecutive days) on IL-1β in mouse hippocampus. Upper panel: Representative photomicrographs showing IL-1β immunoreactive cells in: (a) vehicle inoculated mice (control), (b) Aβ inoculated mice, (c) Aβ inoculated and CBD (2.5 mg kg−1) i.p. treated mice, (d) Aβ inoculated and CBD (10 mg kg−1) i.p. treated mice. Lower panel: Quantification of immunoreactivity expressed as the number of cells immunostained with anti- IL-1β antibody. Data are shown as mean±s.e.m. of five experiments. ***P<0.001 versus control; °P<0.05, and °°°P<0.001 versus Aβ inoculated mice.