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Basal left-ventricular developed pressure (LVDevP) (a), maximum rate of systolic contraction (+dp/dtmax) (b) and maximum rate of diastolic relaxation (−dp/dtmax) (c) in nondiabetic and diabetic hearts. Animals were either left untreated or treated with atrasentan, ramipril or with both drugs. Data are mean±s.e.m. of eight hearts. #P<0.05 vs nondiabetic; *P<0.05 vs untreated diabetic.
