Figure 3.
Diastolic function during ischaemia and reperfusion. –dp/dtmax and left-ventricular end-diastolic pressure (LVEDP) were similar in nondiabetic hearts (a, c) but deteriorated in untreated diabetic hearts (b, d). Peak ischaemic contracture was similar in nondiabetic hearts, and doubled in untreated diabetic hearts (e). Atrasentan, ramipril or combination treatment improved –dp/dtmax and restored LVEDP and peak contracture to nondiabetic level. Data are mean±s.e.m. of eight hearts. *P<0.05 vs untreated diabetic (ANOVA-2). B, baseline. #P<0.05 vs nondiabetic.