Table 1.
Baseline characteristics
| Nondiabetic | Diabetic | |
|---|---|---|
| Untreated | ||
| Blood glucose (mM) | 8.1±0.4 | 30.9±1.9# |
| HbA1C (%) | 4.3±0.1 | 10.4±0.9# |
| Fluid intake (ml day−1) | 32±1.6 | 134±12.4# |
| Body weight (g) | 231±5 | 222±4 |
| Heart weight (g) | 0.98±0.02 | 0.96±0.02 |
| Heart/body weight | 0.0042±0.0001 | 0.0043±0.0001 |
| Blood pressure (mm Hg) | 110±2 | 132±5# |
| Heart rate (min−1) | 383±10 | 319±10# |
| Atrasentan-treated | ||
| Blood glucose (mM) | 8.1±0.5 | 29.7±1.4# |
| HbA1C (%) | ND | 11.1±0.8 |
| Fluid intake (ml day−1) | 33±1.9 | 118±11.6# |
| Body weight (g) | 232±7 | 214±12 |
| Heart weight (g) | 1.00±0.03 | 0.97±0.04 |
| Heart/body weight | 0.0043±0.0001 | 0.0046±0.0002 |
| Blood pressure (mm Hg) | 113±2 | 118±3* |
| Heart rate (min−1) | 391±9 | 301±7# |
| Ramipril-treated | ||
| Blood glucose (mM) | 7.6±0.3 | 31.0±1.3# |
| HbA1C (%) | ND | 10.4±1.0 |
| Fluid intake (ml day−1) | 38±2.3 | 133±13.2# |
| Body weight (g) | 221±6 | 201±4# |
| Heart weight (g) | 0.96±0.03 | 0.90±0.03 |
| Heart/body weight | 0.0044±0.0002 | 0.0045±0.0001 |
| Blood pressure (mm Hg) | 106±4 | 116±4* |
| Heart rate (min−1) | 398±9 | 301±7# |
| Combination-treated | ||
| Blood glucose (mM) | 7.9±0.6 | 32.6±0.7# |
| Fluid intake (ml day−1) | 36±1.8 | 112±9.1# |
| HbA1C (%) | ND | 10.3±0.6 |
| Body weight (g) | 228±6 | 172±11#,* |
| Heart weight (g) | 0.95±0.01 | 0.88±0.03#,* |
| Heart/body weight | 0.0042±0.0001 | 0.0052±0.0003#,* |
| Blood pressure (mm Hg) | 108±3 | 106±4* |
| Heart rate (min−1) | 380±5 | 300±7# |
Data are mean±s.e.m. derived from eight animals per group. #P<0.05 vs corresponding nondiabetic group; *P<0.05 vs diabetic untreated group. ND, not determined.
#
P<0.05
*
P<0.05