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(a) The structure of the KP pre-pro-protein KP-145 in human, rat and mouse. Amino acid sequence of human KP-54 and rat and mouse KP-52 is given. Amino acids in bold are conserved cross-species. (b) [125I]KP-13 has been used to pharmacologically characterize KISS1 (GPR54) in native human tissue (Mead et al., 2006) and [125I]KP-10 in cell lines artificially expressing the receptor (Kotani et al., 2001). SP, signal peptide.
