Figure 4.
Effect of adrenalectomy and RU 38486 treatment on expression of P- or E-selectin on endothelial cell membranes. Vehicle-treated (VT) or RU 38486 was administered for 7 days (10 mg kg−1, i.p., every 24 h) and cremaster muscle was collected 24 h after last doses or 7 days after adrenalectomy or sham surgery. The expressions of P- or E-selectin were quantified by immunohistochemistry. Results are expressed as the mean±s.e.mean of values obtained from three animals in each group. Assays were performed in quadruplicate. NM, non-manipulated; SO, sham-operated; VT, vehicle treated; ADX, adrenalectomized; RU, RU 38486-treated rats.