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. 2007 Oct 29;152(8):1207–1214. doi: 10.1038/sj.bjp.0707534

Figure 3.

Figure 3

Effect of C-18 in proliferation and capillary morphogenesis. (a) Human umbilical vein endothelial cells (HUVECs) were seeded in 24-well plates, treated with C-18 (1 or 100 pM) or vehicle (dimethylsulphoxide (DMSO)) and allowed to proliferate for 48 h. Cell number was measured using the MTT colorimetric assay. Data are expressed as means±s.e.mean; n=16; *P<0.05 vs control. (b) HUVECs were cultured on growth factor-reduced matrigel in the presence of C-18 (1 nM) or DMSO (control) for 24 h and photographed. Vessel-like network length was determined using image analysis software. Data are expressed as means±s.e.mean; n=6; *P<0.05 vs vehicle. Representative photomicrographs of control and C-18-treated cultures (right). C-18, 2-((1E,Z)-1-benzylidene-5-bromo-2-methyl-1H-inden-3-yl)acetic acid.