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C-18 inhibits neovessel formation in vivo. C-18 or vehicle (dimethylsulphoxide (DMSO) in phosphate-buffered saline) was added to restricted areas of the chorioallantoic membrane (CAM) of fertilized eggs, as described in Materials and methods. After 48 h, CAMs were fixed and vessel length evaluated using image analysis software. Data are expressed as means±s.e.mean; n=30–50 eggs per group; *P<0.05 vs control. C-18, 2-((1E,Z)-1-benzylidene-5-bromo-2-methyl-1H-inden-3-yl)acetic acid.
