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. 2007 Oct 29;152(8):1248–1259. doi: 10.1038/sj.bjp.0707535

Figure 5.

Figure 5

Effect of blocking IP3 receptors with 2-aminoethoxy-diphenylborate (2-APB) on spontaneous transient depolarization (STD) discharge (A) and Ca2+ transients in ASMCs (C) and interstitial cells of Cajal-like cells (ICC-LCs) (D) in the renal pelvis bathed in 1 μM nifedipine. 2-APB (60 μM) blocked STD discharge in a manner associated with a membrane depolarization of 20 mV. (Bi–iii) Sections of trace indicated by a–c in (A) displayed on an expanded time base for better comparison. STDs remain blocked even when the membrane was repolarized upon injection of a constant hyperpolarizing current (Bii). Ca2+ transients in ASMCs (C) and ICC-LCs (D) were blocked in 50 μM 2-APB.