Figure 7.
(A) Blockade of ryanodine-sensitive Ca2+ release produced a concentration-dependent reduction in the synchronistic behaviour of spontaneous transient depolarizations (STD) discharge resulting in a reduction in STD amplitude and ½ width, but an increase in their frequency. (Bi–iii) Sections of trace indicated by a–c in A were displayed on an expanded time base. Superimposing STDs recorded in control PSS (Ci), 30 μM (Cii) or 100 μM (Ciii) ryanodine reveals changes in time course and synchronicity in ryanodine.