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. 2007 Nov 5;152(8):1260–1271. doi: 10.1038/sj.bjp.0707519

Figure 4.

Figure 4

PK/PD parameters of NBI-74330 (100 mg kg−1) following oral administration to mice. (a) Blood concentration of NBI-74330 and metabolite-1 at time (h) post-oral dose of 100 mg kg−1 of NBI-74330 in 0.1% sodium docusate/99.9% methyl cellulose (n=3). (b and c) Chemical structures of NBI-74330 and metabolite-1. (d) Effect of plasma samples taken at 1, 4 and 24 h post-oral dose with 100 mg kg−1 NBI-74330 on CXCL11-induced CXCR3 internalization response compared to the E/[A] curve generated in naive mouse plasma (n=3). (e and f) PK/PD relationship of NBI-74330 and metabolite-1, respectively, following oral administration of NBI-74330 (100 mg kg−1). Data are presented as plasma concentration of each antagonist at 1, 4 and 24 h post p.o. dose compared to the degree of inhibition of the CXCR3 internalization response induced by 100 nM CXCL11 (n=3).