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. 2007 Aug 20;152(5):676–690. doi: 10.1038/sj.bjp.0707424

Figure 5.

Figure 5

Levels of oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in RIN m5F β-cells kept on ‘low' (13 mM, G13) and ‘high' (25 mM, G25) glucose for 24 h before stimulation with either glucose (33 mM, 2 h, G33), insulin (100 nM, 2 h) or glucose+insulin (2 h). Data are means±s.e.mean of n=6 separate experiments. *=P<0.05 vs vehicle as assessed by ANOVA followed by the Bonferroni's test. Note that ‘low', ‘high' and ‘very high' glucose do not refer to, nor do they reflect, the fasting concentrations of glucose occurring in humans during normo- or hyperglycaemia, respectively. They refer instead to the optimal culturing conditions of RIN-m5F β-cells, which the manufacturer advises to grow in 25 mM glucose.