Table 1.

Receptor targets of multiple endocannabinoid-like molecules (ECLs)

ECL	CB1	CB2	GPR18	GPR55	GPR119	TRPV1	PPARα	PPARβ/δ	PPARγ
ODA	+1
PEA	+2,3	+2,3		++4	++5	+	++6,7		+8
OEA	+9	+9		++4	+++5	++10	++11,7	++11	+11
AEA	++12,13,14	++12,13		++4	+5	++15	++7		++8
NAGly	+3	+16	+++17			+18
NADA	++19					+++15
2AG	+++14	+++20		++4
Noladin	++14	+21		++4			++7
Virodhamine	−22	++22		+++4			++7

Ligand activity at cannabinoid or cannabinoid-like receptors from three of the four superfamilies (7-transmembrane, transmitter-gated channels and nuclear receptors) of receptor: there is, as yet, no evidence for ECL activation of catalytic receptors. Scale within the target: − antagonist; + weak/no activity; ++ intermediate; +++ high relative activity; a blank space indicates the activity of the ligand has not been described. Indicated are five 7-transmembrane receptors (CB₁, CB2, GPR18, GPR55 and GPR119), one transmitter-gated channel (TRPV1) and three nuclear receptors (PPARα, PPARβ/δ and PPARγ).

¹Leggett et al. (2004); ²Vandevoorde et al. (2003); ³Sheskin et al. (1997); ⁴Drmota et al. (2004); ⁵Overton et al. (2006); ⁶Lo Verme et al. (2005); ⁷Sun et al. (2006); ⁸Bouaboula et al. (2005); ⁹Lin et al. (1998); ¹⁰Movahed et al. (2005); ¹¹Fu et al. (2003); ¹²Felder et al. (1995); ¹³Slipetz et al. (1995); ¹⁴Sugiura et al. (1999); ¹⁵Huang et al. (2002); ¹⁶Sipe et al. (2005); ¹⁷Kohno et al. (2006); ¹⁸Huang et al. (2001b); ¹⁹Bisogno et al. (2000); ²⁰Mechoulam et al., 1995; ²¹Hanus et al., 2001; ²²Porter et al., 2002.