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Dose-related effect of URB602 (10, 5 and 1 mg kg−1 i.p.), administered in a preventive regimen, on oedema, evaluated (a) 2 h, and (b) 24 h after carrageenan, and on thermal hypersensitivity, evaluated (c) 5 h and (d) 24 h after carrageenan. Data represent mean±s.e.m. of 8–10 mice. ***P<0.001 versus non-inflamed; °°°P<0.001 versus inflamed. URB602, [1,1′-biphenyl]-3-yl-carbamic acid, cyclohexyl ester.
